江昀緯
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職稱：
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教授兼系主任
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學歷：
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美國康乃爾大學博士 (2006)
美國康乃爾大學碩士 (2001) 國立中山大學學士 (1998) |
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辦公室位置：
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化學館B14
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辦公室分機：
實驗室分機： |
(03)5715131 ext 33345
(03)5715131 ext 33346 |
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電子信箱：
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個人網站：
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經歷： |
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2017~
2021~ 2015~2021 2012~2017 2007~2012 2006~2007 |
國立清華大學教授
國立清華大學化學系系主任 國立清華大學化學系副主任 國立清華大學副教授 國立清華大學助理教授 博士後研究：美國康乃爾大學 (2006~2007) |
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研究領域： |
| 物理化學、生物物理、生醫分析、電子自旋共振、膜蛋白 本實驗室從事物理化學跨領域研究，利用光譜、磁共振、螢光、顯微鏡等技術探究分子運動，在分子層次描述生物巨分子、分子聚合體的動力學反應與行為、並進行分子動力學計算。實驗室也從事大量生物醫學、細胞膜蛋白的生醫分析與應用。 |
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代表著作： |
| A. Biophysics/Chemical Biology/Apoptosis research |
| A1 |
C.L. Hung, H.H. Chang, S.W. Lee, Y.W. Chiang*, Stepwise activation of the pro-apoptotic protein Bid at mitochondrial membranes, Cell Death & Differentiation, 28 (2021) 1910-1925. |
| A2 |
C.C.Li, T.Y.Kao, C.C.Cheng, Y.W. Chiang*, Structure and regulation of the BsYetJ calcium channel in lipid nanodiscs, Proceedings of the National Academy of Sciences (PNAS), 117 (2020). 30126-30134. |
| A3 |
Y.J. Lan, P.S. Yeh, T.Y. Kao, Y.C. Lo, S.C. Sue, Y.W. Chen, D.W. Hwang*, Y.W. Chiang*, Anti-apoptotic BCL-2 regulation by changes in dynamics of its long unstructured loop, Communications Biology, 3 (2020) 668. |
| A4 |
R.F. Tsai, N.C. Lin, T.Y. Kao, Y.H. Kuo, F.C. Lo, W.F. Liaw, Y.W. Chiang*, Nitrosylation of the Diiron Core Mediated by the N Domain of YtfE, Journal of Physical Chemistry Letters, 11 (2020) 8538-8542. |
| A5 |
Y.J. Lan, Y.T. Wang,C.L. Hung, Y.W. Chiang*, PEGylation-based strategy to identify pathways involved in the activation of apoptotic BAX protein, BBA - General Subjects, 1864 (2020) 129541. |
| A6 |
Y.C. Lai, C.C. Li, T.C. Sung, C.W. Chang, Y.J. Lan, and Y.W. Chiang*, The Role of Cardiolipin in Promoting the Membrane Pore-forming Activity of BAX Oligomers, BBA Biomembranes, 1861 (2019) 268-280. |
| B. Physical Chemistry/Nanochannels/Water Dynamics |
| B1 |
Y.H. Kuo and Y.W. Chiang*, Slow Dynamics around a Protein and Its Coupling to Solvent, ACS Central Science, 4 (2018) 645-655. |
| B2 |
K.J. Chang+, Y.H. Kuo+, and Y.W. Chiang*, Study of Protein Dynamics under Nanoconfinement by Spin-Label ESR: A Case of T4 Lysozyme Protein, Journal of Physical Chemistry B, 121 (2017) 4355–4363. |
| B3 |
T.Y. Kao, C.J. Tsai, Y.J. Lan, andY.W. Chiang*, Role of Conformational Heterogeneity in Regulating the Apoptotic Activity of BAX Protein,Physical Chemistry Chemical Physics, 19 (2017) 9584-9591. |
| B4 |
O. Shih, Y.Q. Yeh, K.F. Liao, T.C. Sung,Y.W. Chiang*, and U-Ser Jeng*, Oligomerization Process of BAX Revealed from Intermediate Structures in Solution, Physical Chemistry Chemical Physics, 19 (2017) 7947-7954. |
| B5 |
YW Huang, YC Lai, CJ Tsai, and YW Chiang*, Mesopores Provide an Amorphous State Suitable for Studying Biomolecular Structure at Cryogenic Temperatures, Proceedings of the National Academy of Sciences (PNAS), 108 (2011) 14145-14150. |
| C. ESR Analysis/Theory |
| C1 |
Y.C. Lai, Y.H. Kuo, and Y.W. Chiang*, Identifying Protein Conformational Dynamics Using Spin‐label ESR, Chemistry - An Asian Journal, 14 (2019) 3981-3991. |
| C2 |
C.C. Li,C.L.Hung, P.S. Yeh, C.E.Li, and Y.W. Chiang*, Doubly spin-labeled nanodiscs to improve structural determination of membrane proteins by ESR, RSC Advances,9 (2019) 9014-9021. |
| C3 |
C.L. Hung, Y.Y. Lin, H.H. Chang, and Y.W. Chiang*, Accessing local structural disruption of Bid protein during thermal denaturation by absorption-mode ESR spectroscopy, RSC Advances, 8 (2018) 34656-34669. |
| C4 |
K.J. Chang+, Y.H. Kuo+, and Y.W. Chiang*, Study of Protein Dynamics under Nanoconfinement by Spin-Label ESR: A Case of T4 Lysozyme Protein, Journal of Physical Chemistry B, 121 (2017) 4355–4363. |
| D. Inorganic/Materials |
| D1 |
Y.Y. Wu, J.C. Hong, R.F. Tsai, H.R. Pan, B.H. Huang, Y.W. Chiang, G.H. Lee, M.J. Cheng,* and H.F. Hsu*, Ligand-Based Reactivity of Oxygenation and Alkylation in CobaltComplexes Binding with (Thiolato)phosphine Derivatives, Inorganic Chemistry, 59 (2020) 4650-4660. |
| D2 |
P. Dai*, Q. Wang, M. Xiang, T.M. Chen, X. Zhang, Y.W. Chiang, T.S. Chan, X. Wang*, Composition-Driven Anionic Disorder-Order Transformations Triggered Single-Eu2+-Converted High-Color-Rendering White-Light Phosphors, Chemical Engineering Journal, 380 (2020) 122508. |
| D3 |
C.H. Ke, C.H. Chen, M.L. Tsai, H.C. Wang, F.T. Tsai,Y.W. Chiang, W.C. Shih, D.S. Bohle, and W.F. Liaw*, {Fe(NO)2}9 Dinitrosyl Iron Complex Acting as a Vehicle for the NO Radical, Journal of the American Chemical Society, 139 (2017) 67-70. |
| D4 |
C.C. Wang, H.C. Chang, Y.C. Lai, H. Fang, C.C. Li, H.K. Hsu, Z.Y. Li, T.S. Lin, T.S. Kuo, F. Neese, S. Ye*,Y.W. Chiang*, M.L. Tsai*, W.F. Liaw*, and W.Z. Lee*, A Structurally Characterized Nonheme Cobalt-Hydroperoxo Complex Derived from its Superoxo Intermediate via Hydrogen Atom Abstraction, Journal of the American Chemical Society, 138 (2016) 14186-14189. |
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Full publication list ==> (Link) |
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