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林俊成教授
職稱: 教授兼系主任                                                  English Version

學歷:

美國史克利普斯研究所博士(1997)
國立台灣大學碩士(1989)
國立清華大學學士(1987)

辦公室位置: 化二館R216
辦公室分機:
實驗室分機:
31287
31288
電子信箱: cclin66@mx.nthu.edu.tw
個人網站: http://m103.nthu.edu.tw/~s103023530/

經歷:

2007 ~ 
2018 ~ 
2006 ~ 2007
2003 ~ 2006
1998 ~ 2003
1997 ~ 1998

國立清華大學教授
國立清華大學化學系系主任
國立清華大學副教授
中研院化學所副研究員
中研院化學所助理研究員
博士後研究:美國史克利普斯研究所

研究領域:

1. Development of new methods for the synthesis of complex carbohydrate antigens.
2. Application of functionalized nanoparticle in glycobiology
3. Study of carbohydrate-protein interaction
4. Fabrication of biomolecule microarray


期刊論文:


  1. Hsiao, H.-Y.;Chen, M.-L.; Wu, H.-T.; Huang, L.-D.; Chien, W.-T.; Yu, C.-C.; Jan, F.-D.; Sahabuddin, Sk; Chang, T.-C.; Lin, C.-C.*“Fabrication of Carbohydrate Microarrays through Boronate Formation”Chem. Comm.201147, 1187-1189.

  2. Huang, L.-D.; Lin, H.-J.;Huang, P.-H.;Hsiao, W.-C.;Reddy, L. V. R.; Fu, S.-L.;* Lin, C.-C.*“Synthesis of serine-based glycolipids as potential TLR4 activators”Org. Biomol. Chem. 20119, 2492-2504.

  3. Chen, C.-C.; Hsu, Wei Hsu; Hwang, K.-C.; Hwu, J. R.; Lin, C.-C.; Horng, J.-C.* “Contributions of cation–p interactions to the collagen triple helix stability”Archives of Biochem. Biophys. 2011508, 46–53.

  4. Wu, H.-T.; Hsu, C.-C.; Tsai,C.-F.; Lin,P.-C.; Lin, C.-C.*; Chen Y-J.*“Nanoprobe-based Immobilized Metal Affinity Chromatography for Sensitive and Complementary Enrichment of Multiply Phosphorylated Peptides”J. Proteomic Res. 2011, ASAP

  5. Tseng, M.-C.; Obena, R.; Lu, Y.-W.; Lin, P.-C.; Lin, P.-Y.; Yen, Y.-S.; Lin, J.-T.; Huang, L.-D.; Lu, K.-L.; Lai, L.-L.; Lin, C.-C.;* Chen, Y.-J.* “Dihydrobenzoic Acid Modified Nanoparticle as a MALDI-TOF MS Matrix for Soft Ionization and Structure Determination of Small Molecules with Diverse Structures”J. Am. Soc. Mass Spect. 2010, 21, 1930-1939.

  6. Ho, J.-a. A.;* Hsu, W.-L.; Liao, W.-C.; Chiu, J.-K.; ChenM.-L.; Chang, H.-C.;Lin, C.-C.“Ultrasensitive Electrochemical Detection of Biotin Using Electrically Addressable Site-Oriented Antibody Immobilization Approach via Aminophenyl Boronic Acid”Biosensors and Bioelectronics 2010, 26, 021–1027

  7. Sahabuddin, Sk; Chang, T.-C.; Lin, C.-C.;Jan, F.-D.;Hsiao, H.-Y.; Huang, K.-T.;Chen, J.-H.;  Horng, J.-C.;Ho, J.-a. A.; Lin, C.-C.*“Synthesis of N-Modified sTn Analogs and Evaluation of Their Immunogenicities by Microarray-Based Immunoassay”Tetrahedron 2010,66, 7510-7519.

  8. Lin, C.-C.;Lin,N.-P.; Reddy, L. V. R.; Sahabuddin, Sk; Huang, L.-D.; Hwang, K. C.; Lin, C.-C.*“5-N,4-O-Carbonyl-7,8,9-tri-O-chloroacetyl-protected sialyl donor for the stereoselective synthesis of α-(2®9)-tetrasialic acid”J. Org. Chem. 75, 4921-4928. (Selected as the Featured Article)2010,

  9. Lai, C.-H.; Lin, C.-Y.; Wu, H.-T.; Chan, H.-S.; Chuang, Y.-J.; Chen, C.-T.; Lin, C.-C.*“Galactose encapsulated multifunctional nanoparticle for HepG2 cell internalization”Adv. Funct. Mater. 201020, 3948-3958.

  10. Chen,J.-C.; Uang,B.-J.; Lyu, P.-C.; Chang, J.-Y.; Liu,K.-J.; Kuo, C.-C.; Hsieh, H.-P.; Wang, H.-C.; Cheng,C.-S.; Chang, Y.-H.; Chang, M. D.-T.;* Chang, W. W.-S.;* Lin, C.-C.*“Design and Synthesis of α-Ketoamides as Cathepsin S Inhibitors with Potential Applications against Tumor Invasion and Angiogenesis”J. Med. Chem. 2010, 53, 4545–4549.

  11. Chang, I.-P.; Hwang, K.-C.;* Ho, J. A.; Lin, C.-C.; Hwu, R. J.-R.; Horng, J.-C.“Facile Surface Functionalization of Nanodiamonds” Langmuir 2010, 26, 3685-3689

  12. Hwu, J.-R.;* Huang, J. J.-T.; Tsai, F.-Y.; Tsay, S.-C.; Hsu, M.-H.; Hwang, K.-C.; Horng, J.-C.; Ho, J. A.; Lin, C.-C.  “Photochemical Activities of N-Nitroso Carboxamides and Sulfoximides and Their Application to DNA Cleavage”Chemistry--A European Journal 2009, 15, 8742-8750.

  13. Lin, P.-C.;Chen,S.-H.; Wang, K.-Y.;Chen, M.-L.; Adak, A. K.;Hwu, J.-R. R. Chen, Y.-J.;* Lin, C.-C.*“Fabrication of Oriented Antibody-Conjugated Magnetic Nanoprobes and Their ImmunoaffinityApplication”Anal. Chem. 2009, 81, 8774-8782.

  14. Chang, S.-S.; Lin, C.-C.; Li, Y.-K.; Mong, K.-K. T.* “A straightforward -selective aromatic glycosylation and its application for stereospecific synthesis of 4-methylumbelliferyl -T-antigen” Carbohydr. Res. 2009344, 432-438.

  15. Ho, J.-a A.; Chiu, J.-K.; Hong, J.-C.; Lin, C.-C.; Hwang, K.-C.; Hwu, J.-R. R.* Gold-nanostructured immunosensor for the electrochemical sensing of biotin based on liposomal competitive assay”J. Nanoscience and Nanotechnology 20099, 2324-2329.

  16. Lin, P.-C.; Adak, A. K.; Ueng, S.-H.; Huang, L.-D.; Huang, K.-T.; Hwu, J.-R. R.; Lin, C.-C.*“DAST-Mediated Regioselective Anomeric Group Migration in Saccharides”J. Org. Chem. 2009,74, 4041-4048. (Selected as the Featured Article)

  17. Lin, C.-C.; Adak, A. K.; Horng, J.-C.; Lin, C.-C.* Phosphite-based Sialic Acid Donors in the Synthesis of (2®9) Oligosialic Acids”Tetrahedron 200965, 4714-4725.

  18. Ho, C.-C.; Lee, L. Y.-L.; Huang, K.-T.; Lin, C.-C.; Ku, M.-y.; Yang,C.-C.; Chan, S. I.; Chen, R. P.-Y.*Tuning the conformational properties of the prion peptide”Proteins: Structure, Function, and Bioinformatics 200976, 213-225.

  19. Liang, C.-F.; Yan, M.-C.; Chang, T.-C.; Lin, C.-C. "Synthesis of S-Linked α(2→9) Octasialic Acid via Exclusive α S-Glycosidic Bond Formation", J. Am. Chem. Soc. 2009131, 3138-3139

  20. Yu, C.-C.; Lin, P.-C.; Lin, C.-C. “Site-specific immobilization of CMP-sialic acid synthetase on magnetic nanoparticles and its use in the synthesis of CMP-sialic acid”,Chem. Commun. 2008, 1308–1310.

  21. Chien, Y.-Y.; Jan, M.-D.; Adak, A. K.; Tzeng, H.-C.; Lin, Y.-P.; Chen,Y.-J.; Wang, K.-T.; Chen, C.-T.; Chen, C.-C.; Lin, C.-C. “ Globotriose-Functionalized Gold Nanoparticles as Multivalent Probes for Shiga-like Toxin”, ChemBioChem 2008, 9, 1100 – 1109.

  22. Shih, P.-H.; Shiu, J.-Y.; Lin, P.-C.; Lin, C.-C.; Veres, T.; Chen, P.  “ On chip sorting of bacterial cells using sugar-encapsulated magnetic nanoparticles”, Journal  of Applied Physics  2008, 103, 07A316.

  23. Chen, M.-L.; Adak, A. K.; Yeh, N.-C.; Yang, W.-B.; Chuang, Y.-J.; Wong, C.-H.; Hwang, K.-C.; Hwu, J.-R. Reuben; Hsieh, S.-L.; Lin C.-C. “Fabrication of an Oriented Fc-Fused Lectin Microarray through Boronate Formation”, Angew. Chem. Int. Ed. 2008,47,  8627 –8630.

  24. Chen, C.-T.; Munot, Y. S.; Salunke, S. B.; Wang, Y.-C.; Lin, R.-K.; Lin, C.-C.; Chen,C.-C.; Liu, Y-H. “ A Triantennary Dendritic Galactoside-Capped Nanohybrid with a ZnS/CdSe Nanoparticle Core as a Hydrophilic, Fluorescent, Multivalent Probe for Metastatic Lung Cancer Cells”, Adv. Funct. Mater. 200818, 527–540.

  25. Hsin, Y.-L.; Lin, C.-F.; Liang, Y.-C.; Hwang, K. C.; Horng, J.-C.; Ho, J.-A. A.; Lin, C.-C.; Hwu, J. R. “ Microwave Arcing Induced Formation and Growth Mechanisms of Core/Shell Metal/Carbon Nanoparticles in Organic Solutions”, Adv. Funct. Mater. 2008,18, 2048–2056.

  26. Wang, K.-Y.; Chuang, S.-A.; Lin, P.-C.;| Huang, L.-S.; Chen, S.-H.; Ouarda, S.; Pan, W.-H.; Lee, P.-Y.; Lin, C.-C.; Chen, Y.-J. “Multiplexed Immunoassay: Quantitation and Profiling of Serum Biomarkers Using Magnetic Nanoprobes and MALDI-TOF MS „, Anal. Chem. 200880, 6159–6167.

  27. Ln, P.-C.;Adak,A. K.; Lin, C.-C.*“Fabrication and Applications of Glyco-nanomaterials” in The Molecular Immunology of Complex Carbohydrates-3, Kluwaer Academic/Plenum Publisher, Wu, A. M. Ed.; 2008in pressed.

  28. Lin, P.-C.; Wu, H.-T.; Wang, K.-Y.; Chen, Y.-J.;* Lin, C.-C.*“Development and Application of Functionalized Nanoparticles on Mass Spectrometry for the Analysis of Target Biomolecules”科儀新知 2008第二十九卷第四期,66-77.

  29. Yan, M.-C.; Chen, Y.-N.; Wu, H.-T.; Lin, C.-C.; Chen, C.-T.; Lin, C.-C.“Removal of Acid Labile Protecting Groups on Carbohydrates Using Water-tolerant and Recoverable Vanadyl Triflate Catalyst”J. Org. Chem. 200772, 299-302.

  30. Huang, L.-S.; Chien, Y.-Y.; Chen, S.-H.; Lin, P.-C.; Wang, K.-Y.; Chou, P.-H.;Lin, C.-C.; Chen, Y.-J. “Nanoprobe-based Affinity Mass Spectrometry for Cancer Marker Protein Profiling” In Nanomaterials for cancer diagnosis; Kumar, C. S. S. R. Eds., Wiley-VCH: New York, 2007; Vol. 7, p338-3763.

  31. Hung LC, Lin CC, Hung SK, et al. “A synthetic analog of alpha-galactosylceramide induces macrophage activation via the TLR4-signaling pathways” Biochemical Pharmacology, 200773 (12): 1957-1970.

  32. Lin PC, Ueng SH, Yu SC, et al. “Surface modification of magnetic nanoparticle
    via Cu(I)-Catalyzed alkyne-azide [2+3] cycloaddition
    ”  Organic Letters, 20079(11): 2131-2134.


  33. Lin CC, Tseng MC, Su AK, et al., “Functionalized magnetic nanoparticles for small-molecule isolation, identification, and quantification “Analytical Chem., 2007,79 (9): 3401-3408.

  34. Lin CC, Teng TM, Odedra A, et al. “Gold-catalyzed deoxygenated cyclization of cis-2,4-dien-1-als with regioselective addition of two nucleophiles. One-pot synthesis of highly functionalized cyclopentene framework”  J. Amer. Chem. Soc., 2007129 (13): 3798

  35. Chiu, T.-C.; Huang, L.-S.; Lin, P.-C.; {C}{C}描述: Anchor{C}.; Lin, C.-C.; Chang, H.-T.*Nanomaterial Based Affinity Matrix-Assisted Laser Desorption/Inonization Mass Spectrometry for Biomolecules and Pathogenic BacteriaRecent Patents on Nanotechnology 20071, 99-111.

  36. Chang, C.-W; Chen, Y.-N.; Adak, A. K.; Lin, K.-H.; Tzou, D.-L.; Lin, C.-C.Synthesis of Phytosphingosine using Olefin Cross-Metathesis: A Convenient Access to Chain-modified Phytosphingosines from D-Lyxose Tetrahedron 2007, 63, 4310-4318.

  37. Liang, F.-C.; Chen, R. P.-Y.; Lin, C.-C.; Huang, K.-T.; Chan, S. I.“Tuning the conformation properties of a peptide by glycosylation and phosphorylation”Biochem. Biophys. Res. Commun. 2006342, 482-488.

  38. Lin, P.-C.; Chou, P.-H.: Chen, S.-H.; Liao, H.-K.; Chen, Y.-J.; Lin, C.-C.“Ethylene Glycol-Protected Magnetic Nanoparticles for Multiplexed immunoassay in Human Plasma” Small 20062, 485-489. (Selected as journal cover)

  39. Lin, P.-C.; Ueng, S.-H.; Tseng, M.-C.; Ko, J.-L.; Huang, K.-T.; Yu, S.-C.; Adak, A. K.; Chen, Y.-J.; Lin, C.-C.“Site-Specific Protein Modification via Copper(I)-Catalyzed 1,2,3-Triazole Formation and Its Implementation in Protein Microarray Fabrication” Angew. Chem. Int. Ed. Engl. 200645, 4286-4290. (Selected as the Hot paper)

  40. Lin, C.-C.; Jan, M.-D.; Weng, S.-S.; Lin, C.-C.; Chen, C.-T.“O-Isopropylidenation of Carbohydrates Catalyzed by Vanadyl Triflate” Carbohydr. Res. 2006341, 1948-1953.

  41. Lin, C.-C.; Huang, L.-C.; Liang, P.-H.; Liu, C.-Y.; Lin, C.-C.“Large Scale Synthesis of Per-O-Acetylated Saccharides and Their Sequential Transformation to Glycosyl Bromides and Thioglycosides”J. Carbohydr. Chem. 2006, 25, 303-313.

  42. Huang K.-T., Wu B.-C., Lin C.-C., Luo, S.-C.; Chen, C.; Wong C.-H., Lin, C.-C.“Multi-enzyme One-pot Strategy for the Synthesis of Sialyl Lewis X-containing PSGL-1 Glycopeptide” Carbohydr. Res. 2006, 341, 2151-2155.

  43. Chen, Y.-J.; Chen, S.-H; Chien, Y.-Y.; Chang, Y.-W.; Liao, H.-K.; Chang, C.-Y.; Jan, M.-D.; Wang, K.-T.; Lin, C.-C. “A Nanoprobe-Based Affinity Mass Spectrometry Approach for Direct Target Protein Identification and Binding Epitope Mapping” ChemBioChem. 2005, 6, 1169-1173.

  44. Sarkar, T. K.; Hazra, A.; Gangopadhya, P.; Panda, N.; Slanina, Z.; Lin, C.-C.;Chen, H.-T “Synthesis of the Necine bases (±)-Macronecine and (±)-Supinidine via an Aza-ene Reaction and Allylsilane Induced Ring Closure” Tetrahedron 200561,1155-1165.

  45. Hsieh, S.-Y.; Jan, M.-D.; Patkar, L. N.; Chen, C.-T.; Lin, C.-C. “Synthesis of PkTrisaccahride with a Carboxyl Functionality Linker” Carbohydr. Res. 2005340, 49-57.

  46. Fan, G.-T.; Pan, Y.-s.; Lu, K.-C.; Cheng, Y.-P.; Wong, C.-H.; Lin, W.-C.; Lin, C.-H.; Fang, J.-M.; Lin, C.-C.; “Synthesis of -Galactosyl Ceramide and the Related Glycolipids for Evaluation of Their Activities on Mouse Splenocytes” Tetrahedron 200561, 1855-1862.

  47. Chen, C.-T.; Weng, S.-S.; Kao, J.-Q.; Lin, C.-C.; Jan, M.-D. “Stripping off water at ambient temperature: Direct atom-efficient acetal formation between aldehydes and diols catalyzed by water-tolerant and recoverable vanadyl triflate” Org. Lett.20057, 3343-3346.

  48. Chou, P.-H.; Chen, S.-H; Liao, H.-K.; Lin, P.-C.; Her, G. R.; Lai, A. C.-Y.; Lin, C.-C.; Chen, Y.-J. “Nanoprobe-Based Affinity Mass Spectrometry for Selected Protein Profiling in Human Plasma” Anal. Chem. 2005, 77, 5990-5997.

  49. Lin, C.-C.; Lin, C.-C.; “N-Trifluoroacetyl Sialyl Phosphite Donors for the Synthesis of(2→9) Oligosialic Acids” Org. Lett20057, 4169-4172.

  50. Chen, F.-Y.; Patkar, L. N.; Ueng, S.-H.; Lin, C.-C.; Lee, A. S.-Y. “Synthesis of -Amino Esters by Regioselective Amination of Allyl Bromides with Aryl and Alkyl Amines” SynLett2005, 2035-2038.

  51. Chen, M.-Y.; Patkar, L. N.;Lu, K.-C.; Lee, A. S.-Y.; Lin, C.-C. “Chmoselective deprotection of acid labile primary hydroxyl-protecting groups under CBr4-photoirradiation conditions” Tetrahedron 2004, 60, 11465-11475.
     
  52. Sarkar, T. K.; Basak, S.; Wainer, I.; Moaddel, R.; Yamaguchi, R.; Jozwiak, K; Chen, H.-T.; Lin, C.-C. “Coaxing a Pyridine Nucleus to Give up its Aromaticity: Synthesis and Pharmacological Characterization of Novel Conformationally Restricted Analogues of Nicotine and Anabasine” J. Med. Chem. 200447, 6691-6701.

  53. Hsu, H.-Y.; Hua, K.-F.; Lin, C.-C.; Lin, C.-H.; Wong, C.-H. “Extract of Reishi Polysaccharides Induces Cytokine Expression via Toll-like Receptor 4-modulated Protein Kinase Signaling Pathways”J. Immunol. 2004, 173, 5989-5999.

  54. Lu, K.-C.; Hsieh, S.-Y.; Patkar, L. N.; Chen, C.-T.; Lin, C.-C.* “Simple and efficient Per-O-acetylation of Carbohydrates by Lithium Perchlorate Catalyst”Tetrahedron 200460, 8967-8973.

  55. Chen, M.-Y.; Patkar, L. N.; Lin, C.-C. “Selective Oxidation of Glycosyl Sulfides to Sulfoxides Using Magnesium Monoperoxyphthalate and Microwave Irradiation” J. Org Chem. 200469, 2884-2887.
     
  56. Lin, C.-C.; Pan, Y.-s.; Patkar, L. N.; Tzou, D.-L. M.; Subramanian, T.; Liu, H.-J.;Lin, C.-C. “A Versatile Approach towards the Synthesis of Novel Seven-Membered Iminocyclitols via Ring-Closing Metathesis – Dihydroxylation Reaction” Bioorg. Med. Chem. 2004, 12, 3259-3267.
     
  57. Lin, C.-C.; Hung, S.-M.; Lee, K.-C.; Cheng, C.-C. “Thermal Stabilization of DNA by a Disaccharide” J. Chin. Chem. Soc. 2004, 51, 655-658.
     
  58. Chen, M.-Y.; Patkar, L. N.; Jan, Mi-Dan.; Lee, A. S.-Y.; Lin, C.-C.“CBr4-photoirradiation protocol for chemoselective deprotection of acid labile primary hydroxyl protecting groups” Tetrahedron Lett. 200445, 635-639.

  59. Chiu, H.-Y.; Tzou, D.-L. M. Patkar, L. N.; Lin, C.-C. “A Facile Synthesis of Phytosphingosine from Diisopropylidene-D-Mannofuranose” J. Org. Chem. 2003, 68, 5788-5791.

  60. Lin, C.-C.; Yeh,Y.-C.; Chen, G.-F.; Yang, C.-Y.; Chen, Y.-C.; Wu, Y.-C.; Chen, C.-C. “Quantitative Analysis of Multivalent Interactions of Carbohydrate Encapsulated Gold Nanoparticles with Concanavalin A” Chem. Comm. 2003, 2920-2921.

  61. Chen, M.-Y.; Patkar, L. N.; Chen, H.-T.; Lin, C.-C. “An efficient and selective method for preparing glycosyl sulfoxides by oxidizing glycosyl sulfides with OXONE or t-BuOOH on SiO2” Carbohydr. Res. 2003338, 1327-1332.

  62. Lin, C.-C.; Fan, G.-T.; Fang, J.-M. “A concise Route to Phyosphingosine from Lyxose” Tetrahedon Lett. 200344, 5281-5283.

  63. Wang, Y-Y.; Khoo, K.-H.; Chen, S-T.; Lin, C.-C.; Wong, C.-H.; Lin, C.-H “Studies on the Immuno-modulating Antitumor Activities of Ganoderma lucidum (Reishi) Polysaccharides: Functional and Proteomic Analyses of a Fucose-containing Glycoprotein Responsible for the Activities” Bioorg. Med. Chem. 200210, 1057-1062.
     
  64. Lin, C.-C.; Yeh, Y.-C.; Yang, C.-Y.; Chen, C.-L.; Chen, C.-F.; Chen, C.-C.; Wu, Y.-C. “Selective Binding of Mannose Encapsulated Gold Nanoparticles on Type 1 Pili in Escherichia coli” J. Am. Chem. Soc. 2002124, 3508-3509.

  65. Chen, M.-Y.; Lu, K.-C.; Lee, A. S.-Y.; Lin, C.-C. “Chemoselective deprotection of primary tert-butyldimethylsilyl ethers on carbohydrate molecules in the presence of secondary silyl” Tetrahedon Lett. 2002, 43, 2777-2780.
     
  66. Lu, K.-C.; Tseng, S.-Y; Lin, C.-C. “5-Azido neuraminic acid thioglycoside as sialylation donor” Carbohydr. Res. 2002337, 755-760.

  67. Chen, P.-Y.; Lin, C.-C.; Chang, Y.-T.; Lin, S.-C.; Chan, S. I. “One O-linked sugar can affect the coil-to- structural transition of the prion peptide” Proc. Natl. Acad. Sci. U.S.A. 200299, 12633-12638.
     
  68. Fan, G.-T.; Lee, C.-C.; Lin, C.-C.; Fang, J.-M. “Stereoselective Synthesis of Neu5Ac(2→5)Neu5Gc-the Building Block of Oligo/Poly(→5-OglycolylNeu5Gc2→) Chains in Sea Urchin Egg Cell Surface Glycoprotein”J. Org. Chem. 2002, 67, 7565-7568.
     
  69. Chang, Y.-P.; Chen, H.-T.; Lin, C.-C. “A convenient and high stereoselectivity approach for -galactosylation performed by galactopyranosyl dibenzyl phosphite with remote participating groups” Tetrahedon Lett. 200243, 7721-7723.

  70. Yu, C.-S.; Niikura, K.; Lin, C.-C.; Wong, C.-H. “The Thioglycoside and Glycosyl Phosphite of 5-Azido Sialic Acid: Excellent Donors for -Glycosylation of Primary Hydroxyls” Angew. Chem. Int. Ed. Engl. 200140, 2900-2903.

     
  71. Lin, C.-C.; Subramanian, T.; Hus, T.-S.; Fan, G.-T.; Lin, C.-C. “Synthesis of C-linked disaccharides via olefin cross-metathesis”,J. Chin. Chem. Soc. 2001, 48,55-58.

  72. Lin, C.-H.; Lin, C.-C. “Enzymatic and Chemical Approaches for the Synthesis of Sialyl Glycoconjugates” in The Molecular Immunology of Complex Carbohydrates-2, Kluwaer Academic/Plenum Publisher, Wu, A. M. Ed.; 2001, 215-230.

  73. Subramanian, T.; Lin, C.-C.; Lin, C.-C. “Synthesis of oxazolidinyl azacycles via ring-closing olefin metathesis : a practical entry to the synthesis of deoxy-azasugars and hydroxypyrrolizidines” Tetrahedon Lett200142, 4079-4082.
     
  74. Lin, C.-C.; Hsu, T.-S.; Lu, K.-C.; Huang , I-T. “Synthesis of -D-Glucopyranosyl1→3)-1-thiol-glucosamine Disaccharide Derivative as Building Block for the Synthesis of Hyaluronic Acid”,J. Chin. Chem. Soc. 200047, 921-928.
     
  75. Fan, G.-T.; Hus, T.-S; Lin, C.-C; Lin, C.-C. “Ring-closing olefin metathesis of prearranged C-allyl saccharides for the synthesis of C- butyl linked homo- and hetero-disaccharides”, Tetrahedon Lett2000, 41, 6593-6597.

  76. Chiu, Y.-J.; Lin, C.-C. “Carbohydrate Antigen and Vaccine” Chemistry 200058,301-308. (Review in Chinese)

     
  77. Lin, C.-C.; Moris-Varas, F.; Weitz-Schmidt, G.; Wong, C.-H. “Synthesis of Sialyl Lewis X Mimetics as Selectins Inhibitors by Enzymatic Aldol Condesation Reactions”, Bioorg. Med. Chem. 19997, 425-433.
     
  78. Wu, W.-G.; Pasternack, L.; Huang, D.-H.; Koeller, K. M.; Lin, C.-C.; Ositz, O.; Wong, C.-H. “Structural Study on O-Glycopeptides: Conformational Differences ofO -GlcNAc, O -LacNAc,O -Sialyl-LacNAc, and O -Sialyl-Lewis-X Petides of the Mucin Domain of MadCAM-1”, J. Am. Chem. Soc. 1999, 121, 2409-2417.

  79. Lin, C.-C.; Lin, C.-H.; Wong, C.-H. “Sialic Acid Aldolase-Catalyzed Condensation of Pyruvate and N-Substituted Mannosamine : A Useful Method for The Synthesis of N-Substituted Sialic Acids”, Tetrahydron Lett. 1997, 38, 2649-2652.

  80. S.-C. Hung; Lin, C.-C.; Wong, C.-H. “One-pot Synthesis of 1-Allyl and 1-Allenyl-6-O-acety-2,3,4,-tri-O-benzyl-α-D-glycosides from Methyl Tetra-O-benzyl-α-D-glycosides”, Tetrahydron Lett. 1997, 38, 5419-5422.
     
  81. Wong, C.-H.; Moris-Varas, F.; Hung, S.-C.; Marron, T. G.; Lin, C.-C.; Gong, K.W.; Weitz-Schmidt, G. “Small Molecules as Structural and Functional Mimics of Sialyl Lewis X in Selectin Inhibition : A Remarkable Enhancement of Inhibition by Additional Negative Charge and/or Hydrophobic Group”, J. Am. Chem. Soc. 1997,119, 8152-8158.

  82. Uchiyama, T.; Woltering, T. J.; Wong, W.; Lin, C.-C.; Kajimoto, T.; Takebayashi, M.; Weitz-Schmidt, G.; Asakura, T.; Noda, M.; Wong, C.-H. “Design an Synthesis of C-Linked Fucosides as Inhibitors of E-Selectin” Bioorg. Med. Chem. 1996, 4, 1149-1165.

  83. Wu, S.-H.; Shimazaki, M.; Lin, C.-C.; Qiao, L.; Moree, W. J.; Wong, C.-H “Synthesis of Fucopeptides as Sialyl Lewis X Mimetics”, Angew. Chem. Int. Ed. Engl. 1996, 35, 88-90.

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專利:

1.       Wong, Chi-Huey; Lin, Chun-Cheng; Lin, Chun-Hung; Chen, Shui-Tein; Khoo, Kay-Hooi; Wang, Yuan-Yuan“Fucose-containing polysaccharides and glycopeptides from Ganoderma lucidum (Reishi) as anti-tumor and immuno modulating agents”
2.     U.S. Patent No. 7,135,183Lin, Chun-Cheng; Chen, Chia-Chun; Wu, Yi-Chun“Carbohydrate encapsulated nanoparticles”U.S. Patent No. 7,695,738 B2

 

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